The Carroll group recently published a method to allow improved ChIP-seq analysis. ChIP-exo greatly increases the resolution of ChIP peaks by digesting away DNA not directly bound by the protein of interest. The method is more involved than traditional ChIP-seq but should allow much less seqeuncig to achieve the same sensitivity.
Their ChIP-exo of the ER pioneer factor FoxA1 identified protected DNA with a predictable 8 bp overhang from the Forkhead motif, which they termed "mesas" due to their similarity to the geological features of the same name.
The Genomics Core performed the sequencing in this study.