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Publication Updates Apr 2014: Neal group demonstrates importance of HES6 in PrCa

last modified Aug 29, 2014 04:38 PM

The Neal group recently published work on HES6 and its importance in prostate cancer. Previous ChIP-seq data showed that AR and c-Myc, bind upstream of the HES6 to positively regulate levels of HES6 mRNA, this paper demonstrates the critical role HES6 playsin maintaining AR activity in prostate cancer, and that it may offer a fresh treatment paradigm in combating this disease.

HES6 drives a critical AR transcriptional programme to induce castration-resistant prostate cancer through activation of an E2F1-mediated cell cycle network

The Genomics Core performed the sequencing and Illumina gene expression microarray work in this study.