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Publication Updates: Mar 2014 Odom group publishes Nature Genetics review

last modified Aug 26, 2014 01:18 PM

The Odom group published the following review in Nature Genetics:

Evolution of transcription factor binding in metazoans - mechanisms and functional implications


Abstract: Differences in transcription factor binding can contribute to organismal evolution by altering downstream gene expression programmes. Genome-wide studies in Drosophila melanogaster and mammals have revealed common quantitative and combinatorial properties of in vivo DNA binding, as well as marked differences in the rate and mechanisms of evolution of transcription factor binding in metazoans. Here, we review the recently discovered rapid 're-wiring' of in vivo transcription factor binding between related metazoan species and summarize general principles underlying the observed patterns of evolution. We then consider what might explain the differences in genome evolution between metazoan phyla and outline the conceptual and technological challenges facing this research field.


The Genomics Core has done lots of ChIP-seq for the Odom group, and some of this was included in this review.